recombinant proteins 4 vinylpyridine merck Search Results


criterion tm xt bis tris protein gel bio rad  (Bio-Rad)
98
Bio-Rad criterion tm xt bis tris protein gel bio rad
Criterion Tm Xt Bis Tris Protein Gel Bio Rad, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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paraformaldehyde  (Tokyo Chemical Industry)
86
Tokyo Chemical Industry paraformaldehyde
Paraformaldehyde, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant proteins 4 octyl itaconate medchemexpress cat  (MedChemExpress)
97
MedChemExpress recombinant proteins 4 octyl itaconate medchemexpress cat
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Octyl Itaconate Medchemexpress Cat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 97 stars, based on 1 article reviews
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paraformaldehyde nacalai tesque  (Nacalai)
86
Nacalai paraformaldehyde nacalai tesque
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Paraformaldehyde Nacalai Tesque, supplied by Nacalai, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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recombinant proteins 4  (Merck & Co)
86
Merck & Co recombinant proteins 4
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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4-hydroxy-3-nitropheylacetyl hapten coupled chicken gamma globulin  (Biomol GmbH)
90
Biomol GmbH 4-hydroxy-3-nitropheylacetyl hapten coupled chicken gamma globulin
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
4 Hydroxy 3 Nitropheylacetyl Hapten Coupled Chicken Gamma Globulin, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant proteins 4 methoxybenzenediazonium tetrafluoroborate  (Thermo Fisher)
93
Thermo Fisher recombinant proteins 4 methoxybenzenediazonium tetrafluoroborate
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Methoxybenzenediazonium Tetrafluoroborate, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant proteins 4 thiouracil thermo scientific chemicals ac359930010 dynabeadstm oligo dt  (Thermo Fisher)
93
Thermo Fisher recombinant proteins 4 thiouracil thermo scientific chemicals ac359930010 dynabeadstm oligo dt
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Thiouracil Thermo Scientific Chemicals Ac359930010 Dynabeadstm Oligo Dt, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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recombinant proteins 4 aminopyridine tocris  (Tocris)
95
Tocris recombinant proteins 4 aminopyridine tocris
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Aminopyridine Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant proteins 4 octyl itaconate professor richard hartley  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology recombinant proteins 4 octyl itaconate professor richard hartley
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Octyl Itaconate Professor Richard Hartley, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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recombinant proteins 4 thiouridine s4u alfa aesar aaj60679 mc methane thiosulfonate biotin xx  (Biotium)
96
Biotium recombinant proteins 4 thiouridine s4u alfa aesar aaj60679 mc methane thiosulfonate biotin xx
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 Thiouridine S4u Alfa Aesar Aaj60679 Mc Methane Thiosulfonate Biotin Xx, supplied by Biotium, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant proteins 4 x laemmli  (Bio-Rad)
99
Bio-Rad recombinant proteins 4 x laemmli
Figure <t>1.</t> <t>4-Octyl</t> itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.
Recombinant Proteins 4 X Laemmli, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure 1. 4-Octyl itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.

Journal: Cell reports

Article Title: 4-Octyl itaconate restricts STING activation by blocking its palmitoylation.

doi: 10.1016/j.celrep.2023.113040

Figure Lengend Snippet: Figure 1. 4-Octyl itaconate inhibits the activation of cGAS-STING pathway (A) Quantitative reverse transcription and polymerase chain reaction (RT-PCR) analysis of Ifnb and Il6 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (B) Immunoblot analysis of indicated proteins in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and transfected with ISD (2 mg/mL) for another 6 h. (C) ELISA of IFN-b and IL-6 secretion in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with ISD (2 mg/mL) for another 8 h.

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rabbit anti-IRG1 Abcam Cat# ab222411, RRID: AB_2868510 Rabbit anti-cGAS (D3O8O) (Mouse specific) Cell Signaling Technology Cat# 31659, RRID: AB_2799008 Rabbit anti-cGAS (E5V3W) Cell Signaling Technology Cat# 79978, RRID: AB_2905508 Rabbit anti-STING/TMEM173 Proteintech Cat# 19851-1-AP, RRID: AB_10665370 Rabbit anti-p-STING (S365) (D8F4W) Cell Signaling Technology Cat# 72971, RRID: AB_2799831 Rabbit anti-IRF3 Proteintech Cat# 11312-1-AP, RRID: AB_2127004 Rabbit anti-p-IRF3 (S396) (4D4G) Cell Signaling Technology Cat# 4947, RRID: AB_823547 Rabbit anti-TBK1 (D1B4) Cell Signaling Technology Cat# 3504, RRID: AB_2255663 Rabbit anti-p-TBK1(S172) (D52C2) Cell Signaling Technology Cat# 5483, RRID: AB_10693472 Mouse anti-b-Actin (8H10D10) Cell Signaling Technology Cat# 3700, RRID: AB_2242334 Rabbit anti-GAPDH (14C10) Cell Signaling Technology Cat# 2118, RRID: AB_561053 Rabbit anti-NRF2 (D1Z9C) Cell Signaling Technology Cat# 12721, RRID: AB_2715528 Bacterial and virus strains HSV-1 F Strain Zhengfan Jiang’s lab N/A HSV1-GFP Zhengfan Jiang’s lab N/A Chemicals, peptides, and recombinant proteins 4-Octyl Itaconate MedChemExpress Cat#HY-112675 Itaconate Sigma-Aldrich Cat#I29204 Itaconate-alkyne (ITalk) MedChemExpress Cat#HY-133870 Protease Inhibitor Cocktail Thermo Fisher Scientific Cat#78430 Phosphatase inhibitor Cocktail Thermo Fisher Scientific Cat#A32957 HT-DNA Sigma-Aldrich Cat#D6898 PMA Sigma-Aldrich Cat#P1585 Anti-Flag M2 Magnetic Beads Sigma-Aldrich Cat#M8823 Streptavidin Agarose Resin Thermo Fisher Scientific Cat#20347 Passive lysis buffer Promega Cat#E194A Luciferase Assay Reagent Promega Cat#E1483 Lipofectamine 3000 Transfection Kit Invitrogen Cat#L3000015 TRIzol Reagent Invitrogen Cat#15596018 RIPA Lysis Buffer Beyotime Cat#P0013B DMXAA MedChemExpress Cat#HY-10964 cGAMP MedChemExpress Cat#HY-100564A TBTA ligand Sigma-Aldrich Cat#678937 TCEP Beyotime Cat#ST045 Biotin-Azide Sigma-Aldrich Cat#762024 Cu2SO4 Sigma-Aldrich Cat#451657 C176 Sigma-Aldrich Cat#SML2559 Dimethyl fumarate MedChemExpress Cat#HY-17363 Monomethyl fumarate MedChemExpress Cat#HY-103252 Ethyl pyruvate MedChemExpress Cat#HY-Y1362 Dimethyl malonate MedChemExpress Cat#HY-Y1787 Lactate sodium MedChemExpress Cat#HY-B2227B 2-Ketoglutaric acid MedChemExpress Cat#HY-W013636 (Continued on next page) Cell Reports 42, 113040, September 26, 2023 15

Techniques: Activation Assay, Reverse Transcription, Polymerase Chain Reaction, Reverse Transcription Polymerase Chain Reaction, Expressing, Transfection, Western Blot, Enzyme-linked Immunosorbent Assay

Figure 2. 4-Octyl itaconate targets STING in the cGAS-STING pathway (A) Quantification of the amount of cGAMP in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with HT-DNA (2 mg/mL) for another 6 h. (B) RT-PCR analysis of Ifnb and Cxcl10 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and simulated with cGAMP (1 mg/mL) for another 2 h.

Journal: Cell reports

Article Title: 4-Octyl itaconate restricts STING activation by blocking its palmitoylation.

doi: 10.1016/j.celrep.2023.113040

Figure Lengend Snippet: Figure 2. 4-Octyl itaconate targets STING in the cGAS-STING pathway (A) Quantification of the amount of cGAMP in BMDMs pretreated with 4-OI (250 mM) or DMSO for 2 h and transfected with HT-DNA (2 mg/mL) for another 6 h. (B) RT-PCR analysis of Ifnb and Cxcl10 mRNA expression in BMDMs pretreated with indicated concentrations of 4-OI or OMS (250 mM) for 2 h and simulated with cGAMP (1 mg/mL) for another 2 h.

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rabbit anti-IRG1 Abcam Cat# ab222411, RRID: AB_2868510 Rabbit anti-cGAS (D3O8O) (Mouse specific) Cell Signaling Technology Cat# 31659, RRID: AB_2799008 Rabbit anti-cGAS (E5V3W) Cell Signaling Technology Cat# 79978, RRID: AB_2905508 Rabbit anti-STING/TMEM173 Proteintech Cat# 19851-1-AP, RRID: AB_10665370 Rabbit anti-p-STING (S365) (D8F4W) Cell Signaling Technology Cat# 72971, RRID: AB_2799831 Rabbit anti-IRF3 Proteintech Cat# 11312-1-AP, RRID: AB_2127004 Rabbit anti-p-IRF3 (S396) (4D4G) Cell Signaling Technology Cat# 4947, RRID: AB_823547 Rabbit anti-TBK1 (D1B4) Cell Signaling Technology Cat# 3504, RRID: AB_2255663 Rabbit anti-p-TBK1(S172) (D52C2) Cell Signaling Technology Cat# 5483, RRID: AB_10693472 Mouse anti-b-Actin (8H10D10) Cell Signaling Technology Cat# 3700, RRID: AB_2242334 Rabbit anti-GAPDH (14C10) Cell Signaling Technology Cat# 2118, RRID: AB_561053 Rabbit anti-NRF2 (D1Z9C) Cell Signaling Technology Cat# 12721, RRID: AB_2715528 Bacterial and virus strains HSV-1 F Strain Zhengfan Jiang’s lab N/A HSV1-GFP Zhengfan Jiang’s lab N/A Chemicals, peptides, and recombinant proteins 4-Octyl Itaconate MedChemExpress Cat#HY-112675 Itaconate Sigma-Aldrich Cat#I29204 Itaconate-alkyne (ITalk) MedChemExpress Cat#HY-133870 Protease Inhibitor Cocktail Thermo Fisher Scientific Cat#78430 Phosphatase inhibitor Cocktail Thermo Fisher Scientific Cat#A32957 HT-DNA Sigma-Aldrich Cat#D6898 PMA Sigma-Aldrich Cat#P1585 Anti-Flag M2 Magnetic Beads Sigma-Aldrich Cat#M8823 Streptavidin Agarose Resin Thermo Fisher Scientific Cat#20347 Passive lysis buffer Promega Cat#E194A Luciferase Assay Reagent Promega Cat#E1483 Lipofectamine 3000 Transfection Kit Invitrogen Cat#L3000015 TRIzol Reagent Invitrogen Cat#15596018 RIPA Lysis Buffer Beyotime Cat#P0013B DMXAA MedChemExpress Cat#HY-10964 cGAMP MedChemExpress Cat#HY-100564A TBTA ligand Sigma-Aldrich Cat#678937 TCEP Beyotime Cat#ST045 Biotin-Azide Sigma-Aldrich Cat#762024 Cu2SO4 Sigma-Aldrich Cat#451657 C176 Sigma-Aldrich Cat#SML2559 Dimethyl fumarate MedChemExpress Cat#HY-17363 Monomethyl fumarate MedChemExpress Cat#HY-103252 Ethyl pyruvate MedChemExpress Cat#HY-Y1362 Dimethyl malonate MedChemExpress Cat#HY-Y1787 Lactate sodium MedChemExpress Cat#HY-B2227B 2-Ketoglutaric acid MedChemExpress Cat#HY-W013636 (Continued on next page) Cell Reports 42, 113040, September 26, 2023 15

Techniques: Transfection, Reverse Transcription Polymerase Chain Reaction, Expressing